MAPT and Alzheimer disease: The findings of this longitudinal investigation revealed that lipid rafts serve as a shared platform for the pathological progression of AD.[37] Furthermore, the up-regulation of AMPK, a crucial regulator of ferroptosis lipid peroxidation, not only inhibits phospholipid synthesis but also exerts an inhibitory effect on the phosphorylation of tau protein.[38] Therefore, in addition to being an important marker of ferroptosis, lipid peroxidation also plays a role in AD.