In the process of tilapia farming, it is unknown whether the low oxygen environment affects the infection ability of L. monocytogenes to tilapia, and whether the differential expression of HIF-1α mediates the infection of L. monocytogenes to tilapia by regulating E-cadherin and c-Met, which is the receptor for the InlA and InlB. Here, HIF1A is linked to infection.