ACVR1 and fibrodysplasia ossificans progressiva: Heterozygous germline gene mutations in the ACVR1 gene were found in all patients diagnosed with Fibrodysplasia ossificans progressiva (FOP, OMIM 135000) [104], while approximately 97% of all patients share the exact gene point mutation c.617G>A; (p.R206H) in the chromosome 2 (Table 1).