Together with such morphofunctional changes, HdLy-MVECs challenged with SSc serum also exhibited a reduction in the expression of the lymphatic markers Prox1 and LYVE-1 accompanied by a robust increase in the myofibroblast markers S100A4, α-SMA, COL1A1, and nuclear Snail1. Here, ACTA1 is linked to systemic sclerosis.