Interestingly, the progression from the stable to the acute form is associated with a significant increase in the levels of PRDX4 in correlation with the increase in relevant biomarkers, including Krebs von den Lungen-6 and surfactant protein D. In mice, the overexpression of human PRDX4 worsens the progression of lung fibrosis and reduces the survival time following bleomycin injury. The gene discussed is PRDX4; the disease is pulmonary fibrosis.