In addition, regulators involved in the PI3K/AKT/mTOR pathway, such as ribosomal protein S6 kinase 1 (S6K1), IGF-1, TLR4, and PTEN, may also be associated with the apoptosis/proliferation ratio in GCs of PCOS [36,61,107,109]. The gene discussed is IGF1; the disease is polycystic ovary syndrome.