APBA3 and cancer: Since Mint3 has the potential for promoting cell proliferation and metastasis in various types of cancer cells (e.g., breast cancer, MDA-MB-231; fibrosarcoma, HT-1080; epidermoid carcinoma, A431; non-small cell lung cancer, A549; and urothelial carcinoma, RT-112), the activity of MT1-MMP is also responsible for exhibiting these features of cancer cells [100,101,102] (Figure 2).