As the direct contribution of MT1-MMP on extravasation is not well elucidated, the stable formation of invadopodia by its structural components Tks4/5 and cortactin is a prerequisite feature for extravasation around the extravascular region of murine lung and several cancer cells such as HT-1080 (fibrosarcoma), B16F10 (murine melanoma), MDA-MB-231LN (breast), and T24 (bladder), which share similar phenotypes [74]. This evidence concerns the gene MMP14 and fibrosarcoma.