AQP3 and breast cancer: Interestingly, in MDCK cells, the overexpression of AQP3, AQP4 and AQP5 all decreased collective cell migration [26], but in contrast, decreased AQP5, via knockdown, decreased the collective migration of MCF7 breast cancer cells [31], and AQP5 overexpression in MCF7 cells increased cellular migration [32], indicating that the effect may be cell-type-specific.