Silencing of HNF4α showed similar effects, downregulating WNT5A expression and TCF/LEF signaling, thus confirming that WNT5A is a direct target of HNF4α in GC [64] and that the LKB1/AMPK/HNF4α/WNT5A axis constitutes a signaling cascade that might play a main role in GC tumorigenesis. The gene discussed is HNF4A; the disease is gastric cancer.