PPARGC1A and hepatocellular carcinoma: Zhang and coworkers [89] further investigated these aspects and found, via RNA-seq analysis, that the expression of BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor), a survival-related gene target of the Wnt/β-catenin signaling pathway, was significantly upregulated in HCC cells when PPARGC1A was knocked down.