Querying MiPanda RNAseq server [40], an application that contains normalized transcriptome data from normal breast samples as the control versus primary and metastatic breast cancer samples, it could be observed that nine of these genes, except HIF1A and LCN2, were found significantly regulated in cancer samples (primary and metastatic) as compared to normal breast control (Supplemental Figure S2). The gene discussed is HIF1A; the disease is breast cancer.