Interestingly, Metformin, a hypoglycemic drug used to treat diabetic patients, rescued AQP7 expression to induce insulin secretion in the rat in vitro and in vivo models of type 2 diabetes by suppressing the Mitogen-Activated Protein Kinase p38 and c-Jun N-terminal kinase (JNK) pathway [312]. Here, INS is linked to type 2 diabetes mellitus.