In Epstein-Barr virus (EBV)-associated gastric cancer, the EBV-encoded protein latent membrane protein 2A (LMP2A) could down-regulate AQP3 by inhibiting the activation of Mechanistic Target Of Rapamycin Kinase (mTOR) signaling pathway and further inhibit autophagy and migration of gastric cancer cells [135]. The gene discussed is AQP3; the disease is gastric cancer.