Furthermore, AQP3 increased the expression of Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4ABP1 also named 4E-BP1; a target of mTOR) and its phosphorylation by activating Mitogen-Activated Protein Kinase 1 (MAPK1; also named Extracellular Signal-Regulated Kinase (ERK)) signaling pathway, which induced autophagy and promoted cell proliferation in gastric cancer cells [135]. Here, MAPK1 is linked to gastric cancer.