ULK1 and gastric cancer: Mechanistically, AQP5 regulated the autophagy and stemness of gastric cancer stem cells by recruiting E3 ligase Tripartite Motif Family Like 1 (TRIM21) to the key autophagy protein Unc-51 Like Autophagy Activating Kinase 1 (ULK1) and inducing the ubiquitination of ULK1 [134].