Moreover, chronic exposure of vaccine cells to H6 in an autocrine manner activates the Janus Kinase 1-Signal Transducer and Activator of Transcription 3-Octamer-Binding Transcription Factor 4 (JAK1-STAT3-OCT4) pathway, resulting in a shift towards a melanoma stem-cell-like phenotype or induced stem cell phenotype. The gene discussed is STAT3; the disease is melanoma.