A mechanistic study further revealed that cardiac-activated CD4+ T cells can transport excessive miR-142-3p via EVs into cardiac fibroblasts in which miR-143-3p activates the WNT signaling pathway by targeting APC (adenomatous polyposis coli) to transform cardiac fibroblasts into activated myofibroblasts boosting post-ischemic ventricular remodeling in the progression of HF [108]. Here, APC is linked to hydrops fetalis.