Necroptosis revealed that the programmed cell death necrosis mechanism [2] is induced in ischemic stroke, triggered by the phosphorylation of receptor-interacting protein kinase-1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and mixed lineage kinase domain-like (MLKL) [3]. This evidence concerns the gene MLKL and ischemic stroke.