Figure 2B,C summarize the numbers of differentially expressed genes for these groups and their annotations, respectively (complete gene lists are available under GEO accession number GSE139605). As expected from the overlap of genes differentially expressed in the glaucoma and aged groups, many canonical pathways predicted to be activated or attenuated in glaucoma or age were similar. This included the endothelin-1, interleukin-6, and Stat3 pathways, whose roles in glaucomatous nerves have been described before [12,13,34]. The gene discussed is STAT3; the disease is glaucoma.