Upon activation, this integrin selectively upregulates the expression of matrix metalloproteinase 2 (MMP2) and the activation of JNK1 in multiple prostate cancer cells in vitro, which plays a crucial role in promoting the osteolysis of bone metastasis (refers to integrin αvβ6 in Table 1) [25]. The gene discussed is MAPK8; the disease is prostate cancer.