CISD1 and Huntington disease: cisd-1 is the single ortholog of CISD1/MitoNEET and CISD2/NAF-1 in C. elegans, and mutants display common features observed in mammals such as damage to motor neurons, disruption of ETC, reduced lifespan and altered proteostasis, as evidenced by increased neurodegeneration in aggregation-prone nematodes expressing polyQ40 (Huntington’s disease) and mutated alfa-synuclein (Parkinson’s disease) [15].