In pancreatic ductal adenocarcinoma, the necroptotic pathway can remodel the immunosuppressive tumor microenvironment via CXCL1 and Mincle signaling, or switch tumor‐associated macrophages toward an M2‐like phenotype, which promotes immune tolerance and immunotherapeutic resistance and induces disease progression.24, 25. This evidence concerns the gene CXCL1 and pancreatic ductal adenocarcinoma.