In pancreatic ductal adenocarcinoma, the necroptotic pathway can remodel the immunosuppressive tumor microenvironment via CXCL1 and Mincle signaling, or switch tumor‐associated macrophages toward an M2‐like phenotype, which promotes immune tolerance and immunotherapeutic resistance and induces disease progression.24, 25. The gene discussed is CLEC4E; the disease is pancreatic ductal adenocarcinoma.