With this exception, HFruD-fed ob/ob HKO mice showed a similar phenotype to NCD-fed ob/ob HKO mice that was characterized by relative fasting hypoglycemia, improved glucose tolerance, and ameliorated hepatic steatosis (Figure 3, F–I), albeit with an unchanged plasma insulin level in the fed state (Supplemental Figure 5C). Here, INS is linked to steatosis.