These differences were associated with a 40% lower food intake (Figure 6A and Supplemental Figure 4A), 35% lower level of hyperinsulinemia in the fed state (Figure 2C and Figure 6I), and lower protein expression of hepatic lipogenic enzymes (Figure 6L and Supplemental Figure 6A) in Mc4r-KO F/F mice. The gene discussed is MC4R; the disease is hyperinsulinism.