ACLY and metabolic dysfunction-associated steatotic liver disease: Hepatic ACLY depletion in db/db mice (57) or mice fed a high-sucrose, high-fat diet (HSHFD) (58) thus ameliorated NAFLD but had no effect on impaired glucose metabolism, whereas ablation of hepatocyte ACC1 in HSHFD-fed mice affected neither NAFLD nor glucose metabolism (59).