Due to the dependence of the PPV and NPV on the prevalence of outcome (frequency of CRP or CRC in the primary studies), they were not entered into the combination data used in the meta-analysis.47,48 The abovementioned measures were combined using the “midas” module in STATA.49 The summary ROC was also used to combine sensitivity and specificity of primary studies separately for CRP and CRC.50 The gene discussed is CRP; the disease is colorectal carcinoma.