LGALS4 and Huntington disease: Moreover, given the similar amount of GS transcript levels between control and HD flies – despite high glycogen levels in the latter – and given the mild phenotypes we observed in HD flies comprising knocked down GS, modulation of endogenous GS protein by using more-advanced expression systems, such as the auxin-inducible GAL4-compatible system described by McClure et al. (2022), could be a way to further uncover the role of GS in HD pathology.