Furthermore, integrin α5β1 binding to the secreted protein Tubulointerstitial nephritis antigen-like 1 (Tinagl1), which also involves αvβ1 and epidermal growth factor receptor (EGFR), results in suppressing triple-negative breast cancer progression and metastasis (Shen et al. 2019; Trerotola et al. 2013). Here, TINAGL1 is linked to triple-negative breast carcinoma.