Furthermore, carboplatin-resistant ovarian cancer cells exhibit upregulation of ADP ribosylation factor 4C (ARL4C), a member of the ADP ribosylation factor subfamily, and Notch-RBP-Jκ-H5K3Me4, a member of the oxysterol-binding protein family (OSBP), resulting in the upregulation of OSBPL5, a member of the OSBP family, promoting cholesterol accumulation and autophagy, leading to carboplatin resistance (63). The gene discussed is OSBP; the disease is ovarian cancer.