PUM1 and breast cancer: This effect was not exacerbated when the Pumilio 1 and 2 proteins were concomitantly targeted with NORAD. Targeting Pumilio proteins separately (Figure S9) also resulted in some accumulation of γH2AX, although not equivalent to NORAD KD (Figures 4A and 4C), demonstrating a multifaceted role for Pumilio family of proteins in the setting of doxorubicin-induced DNA damage in breast cancer cells.