E2F3 and cancer: These opposing results may be explained by the distinctive interacting partners of NORAD, as it is known to sponge a myriad of miRNAs, albeit binding preferentially to PUMILIO proteins known to repress mRNAs involved in mitosis, DNA repair, and replication (e.g., PRC1, PARP1, and WDHD1),9,12 but also repress mRNAs involved in various cancer pathways (e.g., E2F3).52