scRNAseq of cells isolated from the brainstem of symptomatic SOD1 mice and wildtype counterparts depicted transcriptional changes in ALS OLs for genes involved in neurogenesis, CNS development, and ensheathment of neurons (Liu et al., 2020), thus implying a role for oligodendrocytes also in this disorder (Table 1, GSE178693). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.