We recently reported that administration of 5 and 10 mg/kg of DHM delivered via intraperitoneal (i.p.)injection significantly protected the livers of mice from ethanol-induced steatosis and improved mitochondrial health via the AMP-activated protein kinase (AMPK), sirtuin-1 (SIRT1), PPARG coactivator-1α (PGC-1α) signaling pathway (18, 21). This evidence concerns the gene SIRT1 and steatosis.