PPARA and fatty liver disease: The imbalance between nuclear receptors (liver-X-receptor α, retinoid acid receptor α, and peroxisome proliferator-activated receptor α [PPARα]) and their target genes (ATP-binding cassette transporter A1, sterol regulatory element binding protein 1c [SREBP1c], and fatty acid synthase [FAS]) likely drives hepatic steatosis in aged patients (14).