Recent research found that Exosomes from adipose mesenchymal stem cells improve pheochromocytoma cell (PC12 cell) function by activating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) pathway, which was a key pathophysiology of pheochromocytoma (30). The gene discussed is AKT1; the disease is hereditary pheochromocytoma-paraganglioma.