LTF and osteoporosis: In senescent osteoblasts derived from SAMP6 mice (senescence-accelerated mouse-prone 6), an established model of accelerated aging that display several age-related phenotypes, including osteoporosis, sarcopenia, and cognitive decline, Lf enhanced the activity of the IGF1-Akt-mechanistic target of rapamycin (mTOR)signaling pathway.