When switching from is-CGM (FreeStyle Libre version 1) to rt-CGM (Dexcom G4) in 18 adult patients with T1DM, without changing insulin therapy management, there was an increase in TIR, a decrease in time below average (TBR), and no change in time above average (TAR) (44). The gene discussed is INS; the disease is type 1 diabetes mellitus.