The LRP2 gene encodes megalin receptor protein that binds to VDBP 25(OH) D complex and participate in renal reabsorption of this complex.26 It has been suggested that genetic variants in LRP2 might affect 25 (OH) D level.27 Our detection of rs2075252 SNP in the participated family with Vitamin-D deficiency suggests that this SNP might be associated with deficient 25(OH) D level. This evidence concerns the gene LRP2 and vitamin D deficiency.