IL4 and obstructive sleep apnea syndrome: In addition, IL-4 also up-regulates B-cell IgE transcription, enhances IgE mediated eosinophil degranulation, and exacerbates eosinophil mediated airway inflammation.20,21 As shown by Zhang Z et al.22, OSAHS in children has a close bearing on hypertension and serum inflammatory factor levels.