GLP1R and osteoporosis: Drugs used in the treatment of DM such as metformin, sulfonylureas, dipeptidyl peptidase-4 inhibitors (DPP4 inhibitors), insulin, and GLP-1 receptor agonists are noted to be better in terms of osteoporosis.4 It has been also stated that the use of thiazolidinediones and sodium glucose transporter-2 inhibitors (SGLT-2) should be avoided in individuals with diabetes who are at risk of osteoporosis and related fractures.4-8 This study was planned to examine the effects of pioglitazone and dapagliflozin, used in the treatment of T2DM, on the development of osteoporosis in postmenopausal women.