Drugs used in the treatment of DM such as metformin, sulfonylureas, dipeptidyl peptidase-4 inhibitors (DPP4 inhibitors), insulin, and GLP-1 receptor agonists are noted to be better in terms of osteoporosis.4 It has been also stated that the use of thiazolidinediones and sodium glucose transporter-2 inhibitors (SGLT-2) should be avoided in individuals with diabetes who are at risk of osteoporosis and related fractures.4-8 This study was planned to examine the effects of pioglitazone and dapagliflozin, used in the treatment of T2DM, on the development of osteoporosis in postmenopausal women. This evidence concerns the gene INS and diabetes mellitus.