CRYBB2 and nuclear cataract: Furthermore, in the 2nd family, the phenotype we observed is similar to an Indian family with a distinct gene mutation and a central nuclear cataract.27 G161G is the first silent novel mutation reported for lamellar and nuclear cataracts, and thus, our Pakistani families provided new phenotypes related to CRYBB2. These findings and clinical evidence suggested that the heterozygous mutation c.499GA (p.G161G) in exon 6 of the CRYBB2 gene is the cause of congenital cataracts in these families.