22With the advancement of molecular genetic tools in recent years, an increasing number of research organizations have focused on congenital cataract genetic abnormalities. Using direct Sanger sequencing, we discovered a new variant c.499GA (p.G161G) in the exon 6 of CRYBB2 in a five generation Pakistani family with autosomal dominant congenital cataract.22 Here, CRYBB2 is linked to autosomal dominant cataract.