It has been recognized that there is an intimate association between the levels of postoperative tumor markers and the risk of tumor recurrence.8 SIL2 can inhibit the immune function of the body; PTN is a pleiotropic growth factor and has a variety of biological functions that can cause tumor cell metastasis and proliferation.9 CCSA-2 plays an important role in evaluating the prognosis of diseases, which is a colon cancer-specific molecule.10 In the present study, the levels of CCSA-2, PTN and SIL2 in the study group were lower than those in the control group after treatment. The gene discussed is PTN; the disease is malignant colon neoplasm.