The activation of the inflammasome pathway can lead to the activation and release of pro-inflammatory cytokines such as IL18 and IL1β, which, in a murine model of infection by Cryptosporidium tizzeri, have been shown to promote the production of IFNγ, known to play a crucial role in parasite control (Sateriale et al., 2021). The gene discussed is IL18; the disease is infection.