As shown in Figure 8D, high expression of SERPINE1 was positively correlated with the activities of step 1 and step 4, which represents the release of cancer cell antigen and the recruiting of immune cells respectively, but negatively correlated with the activities of step 5, 6 and 7, which represents the infiltration of immune cells into tumors, the recognition of cancer cells by T cells, and the killing of cancer cells, in lots of cancer types. The gene discussed is SERPINE1; the disease is cancer.