SERPINE1 and cancer: High SERPINE1 expression was found to be a risk factor for overall survival in several cancers, consistent with the findings of previous studies (Hanekom et al., 2002; Becker et al., 2010; Duffy et al., 2014; Nakatsuka et al., 2017; Jevrić et al., 2019; Sotiropoulos et al., 2019).