According to the CIBERSORT algorithm, SERPINE1 expression was negatively correlated with the infiltration of plasma cells, memory B cells, naïve CD4+ T cells, CD8+ T cells, follicular helper T cells, regulatory T cells, activated NK cells, and resting mast cells and positively correlated with the infiltration of activated memory CD4+ T cells, macrophages, activated mast cells, and neutrophils in most cancers (Figure 9A). Here, CD4 is linked to cancer.