SERPINE1 was found to significantly reduce overall survival in ACC, BLCA, BRCA, CESC, COAD, GBM, HNSC, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, MESO, OV, PAAD, SARC, STAD, THCA, UCEC, and UVM, while it was found to play a protective role for overall survival in PCPG and SKCM (Figure 5A). Here, SERPINE1 is linked to adrenal cortex carcinoma.