The results demonstrated that SERPINE1 expression was positively and significantly correlated with the expression of immune-checkpoints, chemokines, chemokine receptors, and MHC-related genes in most cancers, indicating the remarkable effect of SERPINE1 on the immune system and consistent with previous studies about the pro-inflammatory and pro-angiogenesis roles of SERPINE1 (Iwaki et al., 2012; Declerck and Gils, 2013; Placencio and DeClerck, 2015). This evidence concerns the gene SERPINE1 and cancer.