SERPINE1, a regulator of the fibrinolytic system, was found to be associated with tumor progression and metastasis in several cancers; however, its detailed mechanisms of action in various cancers remain obscure (Hanekom et al., 2002; Becker et al., 2010; Duffy et al., 2014; Mashiko et al., 2015; Jevrić et al., 2019; Sotiropoulos et al., 2019). Here, SERPINE1 is linked to cancer.