BMP2 and infection: And deletion of the β-catenin expression by the infection of Ad-Cre into β-cateninflox/flox osteoblasts may inhibit osthole-stimulated expression of Runx-2, ALP, BSP, and BMP-2, suggesting that BMP-2 acts as the downstream factor of the β-catenin signaling (Tang et al., 2010).