CAL induces p21Waf1/Cip1 cycle arrest and promotes caspase apoptosis and MIA PaCa-2 cell migration in macrophages RAW 264.7, which occurs through the induction of the Raf/MEK/ERK pathway and promotion of M2 tumor-associated macrophages acting in the tumor microenvironment (Zhang et al., 2020). This evidence concerns the gene MAP2K7 and neoplasm.