The downstream mediator of p38 signaling during IAV infection is not clear; P38 MAPK signaling is important for PGE2 production (Mizumura et al., 2003; Li et al., 2020), and genetic deletion of Cox2 as well as PGE2 receptor inhibition have been shown to reduce the severity of influenza infection (Carey et al., 2005; Chen et al., 2022). Here, MAPK14 is linked to influenza.