That cardiomyocyte-specific NCoR1 knockdown exacerbated acute reperfusion-induced cardiac injury through mitochondria-mediated apoptosis (manifested by enlargement of myocardial infarction, reduction of left ventricular contractility, reduction of surviving myocardium, and exacerbation of myocardial inflammatory edema). This evidence concerns the gene NCOR1 and myocardial infarction.