NFKB1 and neoplasm: NF-κB-driven MMP-2, MMP-3 and MMP-9 potentially degrade the basement membrane, perform remodelling of the extracellular matrix and facilitate angiogenesis and metastasis of endothelial cells and tumour cells, respectively (John and Tuszynski, 2001), On the contrary, NF-κB inactivation is reported to abrogate the production of VEGF, supplementary fibroblast growth factor (bFGF), IL-8 and MMP-9 (Huang et al., 2001).