The parallel activation of IκB kinase with Akt/PKB creates a cross-talk between NF-κB and PI3K/Akt/mTOR pathways, which has been reported to aggrandize the inflammogenesis and anti-apoptotic activity in lymphoma cells (Hussain et al., 2012; Li et al., 2018). The gene discussed is AKT1; the disease is lymphoma.