NR1H4 and neoplasm: A high-fat diet increases the bile acid levels in the body, stimulates secondary bile acids levels with tumor-promoting activity in the colon, activates the bile acids-farnesoid X-activated receptor axis, stimulates the colon, and increases Wnt family member 2 B expression in fibroblast cells, thus promoting the formation of tumor immunosuppressive microenvironment (Zeng et al., 2019).