Together, the high level of S100B and Iba1 staining, as well as the subsequent quantification of cell type abundances identified using Hyperion IMC, confirms the strong Schwann cell and macrophage signatures identified using bulk transcriptomics in NF2-SWN and sporadic VS, as well as the similarities in tumour microenvironment components between these tumours. This evidence concerns the gene S100B and neoplasm.