These neoplasms develop from Schwann cells that myelinate the eighth cranial nerve in the internal auditory meatus and cerebellopontine angle.1 In addition to NF2-SWN VS, mutations in NF2 are also noted in 49–66% of the more common sporadic unilateral VS or up to 86% in 181 VS when loss of the NF2 locus on 22q is included.2–5 Patients with VS, whether NF2-SWN or sporadic, present with sensorineural hearing loss, imbalance and tinnitus, which greatly reduce the quality of life. This evidence concerns the gene NF2 and neoplasm.