NF2 and cancer: Close cell–cell interaction between Schwann cells and fibroblasts has been noted in VS and various cancers, with fibroblasts known to promote tumour growth by releasing growth factors and extensively secreting extracellular matrix components thus increasing the fibrotic nature of the VS tumour microenvironment.32,53,54 Importantly, this study identified no difference in the relative estimated abundance of fibroblasts between NF2-SWN and sporadic VS predicted by bulk RNA deconvolution, nor in the abundance of Schwann cells between these tumours by deconvolution and IMC.