MAPT and hypertensive disorder: For example, early adulthood BP may influence brain volume through pathways related to tau pathology,55 hypertension-related infarction,56 or shared common predictors (e.g. genetics), whereas the relationship between midlife BP and white matter damage may be mediated by changes in perfusion and inflammatory processes.54 Since only cognitively unimpaired participants age ∼70 were included in our study, and few individuals have hypertension in early adulthood, the impact of subtle hypertension influences in early adulthood on late-life NAWM metrics may not be apparent in this cohort.