AGT and Hypercholesterolemia: Previous in vitro and in vivo work have shown that 27-OH induces AGT production in the brain, implying a connection between hypercholesterolaemia and hypertension in neurodegeneration.44 In agreement with Mateos et al.,19 we show that AGT is increased in post-mortem hippocampal tissue of Alzheimer’s disease donors compared with controls, suggesting an altered AGT synthesis or cleavage independent of the presence of hypertension, hypercholesterolaemia or diabetes.