We further explored whether the investigated biomarkers of cholesterol dysmetabolism (27-OH) vascular function (AGT, VEGF), inflammation (IL-12/IL-23p40, IL-15), oxidative stress (TRX-1) and glucose homeostasis (ENPP-2) are associated with Alzheimer’s disease pathology, synaptic dysfunction, neurodegeneration and cognition. Here, IL15 is linked to early-onset autosomal dominant Alzheimer disease.