Previous in vitro and in vivo work have shown that 27-OH induces AGT production in the brain, implying a connection between hypercholesterolaemia and hypertension in neurodegeneration.44 In agreement with Mateos et al.,19 we show that AGT is increased in post-mortem hippocampal tissue of Alzheimer’s disease donors compared with controls, suggesting an altered AGT synthesis or cleavage independent of the presence of hypertension, hypercholesterolaemia or diabetes. The gene discussed is AGT; the disease is early-onset autosomal dominant Alzheimer disease.