A limited number of studies have explored TRX-1 distribution in the human Alzheimer’s disease brain so far, with contradictory results, as TRX-1 was found to be either decreased10,41 or unchanged between Alzheimer’s disease and control brains.13 The discrepancies between the different studies could be attributed to methodological or cohort differences, such as the selection of antibodies, or a population free of common comorbidities as in our material. Here, TXN is linked to Alzheimer disease.