In line with the presented data, it has been documented that TRX-1 is involved in inflammation by inducing both pro-inflammatory and anti-inflammatory processes.40 In this study, TRX-1 correlated with AGT and 27-OH, suggesting that it may be implicated in diverse pathological mechanisms occurring in Alzheimer’s disease through its ubiquitous function. This evidence concerns the gene TXN and early-onset autosomal dominant Alzheimer disease.