3’3-Diindolylmethane (DIM) restrains the generation and expansion of RA fibroblast-like synoviocytes (RA-FLSs) via inhibiting the AKT/mTOR pathway, reduces TNF-α-induced cytokines, and alleviates the severity of knee joint arthritis, preventing inflammation and knee joint destruction (80). This evidence concerns the gene AKT1 and rheumatoid arthritis.