Then, GSVA analysis of the two subtypes was performed using KEGG to compare the variation in the enrichment pathways, it was found that DRGGs cluster A was highly enriched in the drug metabolism cytochrome P450, steroid hormone biosynthesis, tyrosine metabolism, PPAR signaling pathway, whereas the remaining pathways, such as cancer pathway, pathogenic E. coli infection and actin cytoskeleton regulation were highly enriched in DRGGs cluster B. (Figure 3E). This evidence concerns the gene PPARA and cancer.