DC-SIGN, which is upregulated in DCs in the lesional skin of atopic dermatitis, can bind to a broad range of common allergens such as house dust mite allergen, egg white allergen, (30) and even transglutaminase 3, which has been proposed as an important autoallergen in atopic dermatitis, highlighting the important role of these cells in the pathogenesis of the disease (31). The gene discussed is TGM3; the disease is atopic eczema.