TNF and allergic contact dermatitis: Furthermore, CBD can elicit anti-inflammatory effects in an allergic contact dermatitis model, where CBD treatment resulted in an elevation in the levels of AEA, and also blocked the increase of IL-6, CXCL8, TNF-α, MCP-2 in polyinosinic-polycytidylic acid-stimulated HaCaT keratinocytes (100).