1、 1, NLRP3 inflammasome activation within the tumor microenvironment can induce the activation of IL-1β, which subsequently activates RORγt to promote the secretion of IL-22 by Th17 cells (105).2、 2, TGF-β, IL-6, and IL-23, promoting the differentiation of Th17 cells and secretion of IL-17 and IL-22 (111)3, CCL20 recruits Th17 cells (119). The gene discussed is TGFB1; the disease is neoplasm.