proposed that within the tumor microenvironment of melanoma (as well as ovarian cancer, breast cancer, and colon cancer), tumor cells and tumor-associated fibroblasts secrete monocyte chemoattractant protein-1 (MCP-1) and RANTES, which mediate the migration of Th17 cells into the tumor microenvironment. The gene discussed is CCL2; the disease is colonic neoplasm.